POLO-LIKE KINASES AND THE ORCHESTRATION OF CELL DIVISION Nature Reviews Molecular Cell Biology 5, 429 -441 (2004); doi:10.1038/nrm1401 | ||
 Рис.1. | Cell-cycle functions and localizations of Plk1.  Рис.2. | Key features of Plks.  Рис.3. | Plk1 activation and polo-box-domain-mediated targeting.  Box 2 | Cdk1 regulation at the G2/M transition  Box3 | The spindle checkpoint and the regulation of anaphase onset  Box4 | Plks in meiosis: lessons from Cdc5 function in S. cerevisiae
| Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis. In agreement with a broad range of proposed functions during cell division, Plks are subject to complex temporal and spatial control. Recent findings are uncovering the mechanisms of Plk regulation, notably their targeting to different cellular structures through interactions with phosphorylated docking proteins. Moreover, information is emerging on the substrate specificity of Plks and the role of individual substrates in M-phase progression. | |