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HEPARAN SULPHATE PROTEOGLYCANS: THE SWEET SIDE OF DEVELOPMENT Kent Nybakken, Norbert Perrimon Nature Reviews Molecular Cell Biology 6, 530-541 (2005); doi:10.1038/nrm1681 | |
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Рисунки
 Рис.1. | Biosynthesis of heparan sulphate, chondroitin sulphate or dermatan sulphate glycosaminoglycans.  Рис.2. | Structure of membrane heparan sulphate proteoglycans.  Рис.3. | Drosophila melanogaster genes involved in synthesis and modification of heparan sulphate.  Рис.4. | Function of glypicans in growth factor signalling.  Рис.5. | Heparan sulphate proteoglycans and Wingless morphogen activity gradients  Box 2 | The Wingless and Hedgehog signalling pathways  Box 3 | The transforming growth factor- (TGF)–Decapentaplegic (Dpp) signalling pathway Табл.1 Drosophila melanogaster genes involved in HS biosynthesis and modification | Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development. |